RESEARCH
Clinical trials are offered though our participation with a variety of regional and national groups including Eastern Cooperative Oncology Group (ECOG), American College of Surgeons Oncology Group (ACOSOG), Cancer Institute of New Jersey (CINJ) and National Institutes of Heath (NIH).

CURRENT PROTOCOLS INCLUDE:

IELCAP - Early Lung Cancer Detection Using Coimputed Tomography

FAMRI - Flight Attendatnt Medical Research Institute-IELCAP Protocol. A multi-disciplinary research and clinical program to enhance early detection and treatment of diseases related to secondhand-smoke (SHS) exposure, with particular attention to emphysema, chronic bronchitis, bronchiectasis, asthma, cardiovascular diseases, sinusitis, osteoporosis, and early detection of cancer.

E1505 - A Phase II Randomized Triual of Adjuvant Chemotherapy with or without Bevacizumab for Patients with Completely Resected Stage IB (>=4cm)°VIIIA Non-Small Cell Lung Cancer (NSCLC)

CASLGB 80403/ (E1206) - A Phase II Study of ECF-C, IC-C, or Folfolx-C in Metastatic Esophageal and GE Junction Cancer

CBKM120D2201 - An open label two-stage study of orally administered BKM120 in patients with metastatic non-small cell lung cancer with activated PI3K pathway.

E5508 - Randomized phase III study of maintenance therapy with bevacizumab, mpemetrexed or a combination of bevacizumab and pemetrexed following carboplatinum, paclitaxel and bevacizumab for advanced non-squammous NSCLC.

PUBLICATIONS
Mark D. Widmann, MD

Widmann MD, Caccavale RJ, Bocage JP, Lewis RJ. Video-assisted thoracic surgery resection of chest wall en bloc for lung carcinoma. The Annals of Thoracic Surgery, 70(6):2138-2140, 2000.

Widmann MD, Caccavale RJ, Bocage JP. Video-assisted thoracic surgical management of malignant pleural effusion in 219 consecutive cases: pleurectomy revisited. Chest 118(4) 120S, 2000.

Widmann MD, Hruska LA, Kernstine KH. Complete video-assisted resection of trilobar mucormycosis. Journal of Laparoendoscopic & Advanced Surgical Techniques 10(4):219-221, 2000.

Lewis RJ, Caccavale R, Bocage JP, Widmann MD. Video-Assisted thoracic surgical non-rib spreading simultaneously stapled lobectomy. Chest 116: 1119-1124, 1999.

Widmann MD, DeLucia A, Sharp WJ, Richenbacher WE. Reversal of renal failure and delayed paraplegia after ruptured thoracoabdominal aortic aneurysm. The Annals of Thoracic Surgery 65:1153-1155, 1998.

Widmann MD, Weintraub N, Fudge J, Brooks LA, Dellsperger KD. Role of the cytochrome p450 pathway in acetylcholine-induced canine coronary microvascular vasodilation in vivo. American Journal of Physiology: Heart Circulation Physiology 274: H283-H289, 1998.

Sumpio BE, Widmann MD, Ricotta J, Awolesi MA, Watase M. Increased ambient pressure stimulates proliferation and morphologic changes in cultured endothelial cells. Journal of Cellular Physiology 158(1): 133-139, 1994.

Awolesi MA, Widmann MD, Sessa WC, Sumpio, BE. Cyclic strain increases endothelial nitric oxide synthase activity. Surgery 116(2):439-445, 1994.

Widmann MD, Sumpio BE. Lipoprotein(a): a risk factor for peripheral vascular disease. Annals of Vascular Surgery 7(5): 446-451, 1993.

Widmann MD, Letsou GV, Baldwin JC, Sumpio BE. Isolation and characterization of rabbit cardiac endothelial cells: response to pulsatile strain in vitro. Journal of Surgical Research 53:331-334, 1992.

Widmann MD, Sumpio BE. Persistent hypoglossal artery: an anomaly leading to a false-positive duplex ultrasonography. Annals of Vascular Surgery 6:176-178, 1992.

Iba T, Maitz S, Furbert T, Rosales O, Widmann MD, Spillane R, Sumpio BE. Effect of cyclic stretch on endothelial cells from different vascular beds. Circulatory Shock 35:193-198, 1991.

Sumpio BE, Widmann MD. Enhanced production of an endothelium-derived contracting factor by endothelial cells subjected to pulsatile stretch. Surgery 108:277-282, 1990.

Hindman NB, Schocken DD, Widmann MD, Anderson WD, White RD, Leggett S, Ideker RE, Hinohara T, Selvester RH, Wagner GS. Evaluation of a QRS scoring system for estimating myocardial infarct size. V. Specificity and method of application of the complete system. American Journal of Cardiology 55:1485-1490, 1985.

Federico A. Steiner, MD

Sequential 5-Aza 2'-deoxycytidine/depsipeptide FK228 treatment induces tissue factor pathway inhibitor 2 (TFPI-2) expression in cancer cells. Federico Steiner, Julie Hong, Marie Fischette, David Beer, Zong-Sheng Guo, G Aoron Chen, Todd S Weiser, Edmund Kassis, Dao Nyugen, Sunmin Lee, Jane B Trepel, David S Schrump Oncogene 2005 March; 24(14):2386-97

Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavoperidol:activation of the mitochondria-dependent death-signaling pathway. Nguyen DM, Schrump WD, Tsai WS, Chen A, Stewart JH, Steiner F, Schrump DS J Thoracic Cardiovas Surg 2003 May;125(5):1132-42

Juxtathyroidal neck soft tissue angiosarcoma presenting as an undifferentiated thyroid carcinoma. Yu J, Steiner F, Meunch JP, Gourgiotis L, Skarulis MC, Altemus RM Libutti SK, Merino MJ, Sarlis MJ Thyroid 2002 May; 12(5)427-32

Lexipafant Inhibits Platelet Activating Factor Enhanced Neutrophil Functions. Schwartz JD, Shamamian P, Grossi EA, Marcus S, Steiner F, Colvin SB, Galloway AC Journal of Surgical Research 1997 May; 69(2):240-8

Cardiopulmonary Bypass Primes Polymorphonuclear Leukocytes. Schwartz JD, Shamamian P, Steiner F, Colvin SB, Galloway AC Journal of Surgical Research 1998 March; 75(2):177-82

Warren D. Widmann, MD

Sugarmann WM, Widmann WD, Mysh R, Sattario R. Mesh insertion as an aid for pleurodesis. Journal of Cardiovascular Surgery 37: S1;173-175, 1996.

Willekes CL, Widmann WD. Empyema from lost gallstones: a thoracic complication of laparoscopic cholecystectomy. Journal of Laparoendoscopic Surgery 6:123-126, 1996.

Squittieri R, Widmann WD, Kelly KM, Weinberg RM, Swayne LC, Squillario D. Does selective left endobronchial suctioning in the intubated ICU patient result in improved radiographic outcome? Critical Care Medicine 24:A179, 1996.

Abkin A, Widmann WD. Bronchial carcinoid tumors: 10 years' experience at a community hospital. The Journal of the Pennsylvania Association for Thoracic Surgery 3:52-56, 1995.

Barraco RD, Widmann WD. Interpleural lidocaine for pain relief in pulmonary surgery. Chest 106:66S, 1994.

Vasselli J, Widmann WD. Predicting air leak resolution post-lung surgery by effluent gas analysis. Chest 106:52S, 1994.

Widmann WD. More on routine chest x-ray film, letter. New England Journal of Medicine 315:460, 1986.

Widmann WD. Surgical pros and cons, endotracheal tube replacement. Surgery, Gynecology, and Obstetrics 161:273, 1985.